MERCK IKLEN Depigmenting Cream
Prevents the Appearance of Brown Spots

• Regulates and prevents brown marks caused by abnormal pigmentation.
• Rucinol^® inhibits melanin production and spots from developing.
• Moisturizing, fragrance-free formula is easily applied, tolerated and absorbed by skin.

30 ml tube

• Apply morning and evening to the hyperpigmented areas, before applying usual skin care (day or night cream, make-up).
• There is no need to limit the application to the darker areas only: Iklen can be safely applied to larger areas.
• Apply softly, without rubbing (friction enhances the overproduction of melanin).
• You can expect to see visible results after 4 weeks and continued improvement over the following months.
• It is recommended that you use Iklen Serum and/or Cream for 8 - 12 weeks.
• Add a high sun protection during sun exposure (minimum SPF 30).

Rucinol®

Rucinol® (a patented ingredient)  works on the biochemical pathway by which melanin (colour in the skin) is produced. 

Rucinol®  inhibits an enzyme called tyrosinase, thereby reducing the production of the darker melanins.

• Rucinol® also inhibits another enzyme called TRP1
• The inhibition of TRP1 will shift production of black melanin towards brown or pale melanins (phaeomelanin).
• Overview of the mode of action:
• By acting in two places (on tyrosinase and TRP1), Rucinol®  reduces and lightens the melanosomes. It is therefore an effective depigmenting agent.

Sophora-alpha

• Sophora-alpha acts on the outside of the melanocyte, and blocks the extracellular action of alpha-MSH, by blocking MSH receptors.
• Alpha-MSH is responsible for activating the melanin synthesis pathway.